West End High School was a public high school in the Birmingham City Schools system of Birmingham, Alabama. The school's massive red-brick building, completed in 1930 was a collaboration between noted local architects Warren, Knight and Davis and David O. Whilldin.

The school, which was open originally to white students only, was integrated in September 1963. A boycott of the school by white students took place after two African-American students tried to register for classes. Those who boycotted shouted Two, four, six, eight, we don't want to integrate. The boycott ended in a week.

On June 27, 1982 West End alumnus and shuttle pilot Henry W. Hartsfield carried a West End banner into orbit aboard the Space Shuttle Columbia. In 2001 then-superintendent Johnny E. Brown proposed merging West End High School and Wenonah High School into a new high school in Oxmoor Valley. The Board of Education approved the name 'Martin Luther King, Jr High School; for the new building, but the consolidation plan was successfully opposed by community groups who feared that vacating the old buildings would damage their neighborhoods.

Part of the school was damaged by a fire which broke out in the basement on January 24, 2003. It was suspected that the fire was intentionally set. Under a consolidation plan approved by the Birmingham Board of Education in February 2008, West End High School was closed during the summer of 2008 with students transferring to Wenonah High School, A. H. Parker High School and Jackson-Olin High School. The closing was marked by a ceremony on June 7 with a parade, pep rally, picnic and alumni basketball game.

Demolition of the school building began in March 2009.