|
Gary Nitti
FOR EVERYONE'S CONSIDERATION:
Underlying Medical Conditions and Severe Illness Among 540,667 Adults Hospitalized With COVID-19,
March 2020–March 2021
Lyudmyla Kompaniyets, PhD ; Audrey F. Pennington, PhD ; Alyson B. Goodman, MD ;
Hannah G. Rosenblum, MD ; Brook Belay, MD ; Jean Y. Ko, PhD ; Jennifer R.
Chevinsky, MD ; Lyna Z. Schieber, DPhil, MD ; April D. Summers, MPH ; Amy M.
Lavery, PhD ; Leigh Ellyn Preston, DrPH ; Melissa L. Danielson, MSPH ; Zhaohui Cui,
PhD ; Gonza Namulanda, DrPH ; Hussain Yusuf, MD ; William R. Mac Kenzie, MD ;
Karen K. Wong, MD ; James Baggs, PhD ; Tegan K. Boehmer, PhD ; Adi V.
Gundlapalli, MD, PhD (View author affiliations)
Suggested citation for this article: Kompaniyets L, Pennington AF, Goodman AB, Rosenblum HG, Belay B, Ko JY, et al. Underlying Medical Conditions and Severe Illness Among
540,667 Adults Hospitalized With COVID-19, March 2020–March 2021. Prev Chronic Dis 2021;18:210123. DOI: http://dx.doi.org/10.5888/pcd18.210123 .
PEER REVIEWED
Abstract
Introduction
Severe COVID-19 illness in adults has been linked to underlying medical conditions.
This study identified frequent underlying conditions and their attributable risk of
severe COVID-19 illness.
Methods
We used data from more than 800 US hospitals in the Premier Healthcare Database
Special COVID-19 Release (PHD-SR) to describe hospitalized patients aged 18 years
or older with COVID-19 from March 2020 through March 2021. We used
multivariable generalized linear models to estimate adjusted risk of intensive care
unit admission, invasive mechanical ventilation, and death associated with frequent
conditions and total number of conditions.
Results
Among 4,899,447 hospitalized adults in PHD-SR, 540,667 (11.0%) were patients with
COVID-19, of whom 94.9% had at least 1 underlying medical condition. Essential
hypertension (50.4%), disorders of lipid metabolism (49.4%), and obesity (33.0%)
were the most common. The strongest risk factors for death were obesity (adjusted
risk ratio [aRR] = 1.30; 95% CI, 1.27–1.33), anxiety and fear-related disorders (aRR =
1.28; 95% CI, 1.25–1.31), and diabetes with complication (aRR = 1.26; 95% CI, 1.24–
1.28), as well as the total number of conditions, with aRRs of death ranging from
1.53 (95% CI, 1.41–1.67) for patients with 1 condition to 3.82 (95% CI, 3.45–4.23) for
patients with more than 10 conditions (compared with patients with no conditions).
Conclusion
Certain underlying conditions and the number of conditions were associated withsevere COVID-19 illness. Hypertension and disorders of lipid metabolism were themost frequent, whereas obesity, diabetes with complication, and anxiety disorders were the strongest risk factors for severe COVID-19 illness. Careful evaluation andmanagement of underlying conditions among patients with COVID-19 can helpstratify risk for severe illness.
Gary
|
Okay. So. Question. 
